To Contact Us:
Dr. Nada Abumrad
Robert C Atkins Professor of Obesity Research in Medicine
Center for Human Nutrition
Washington University in St. Louis
nabumrad@wustl.edu  314-747-0348
The Abumrad Lab
Washington University in St. Louis
Box 8031, 507 S. Euclid
St. Louis, Missouri USA  63110
314-362-8206 (lab phone)

Selected publications

Evidence for membrane protein facilitation of cellular fatty acid (FA) uptake:

  • Harmon CM, Abumrad NA. Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids. J Membrane Biol. 133(1):43-9, 1993.

  • Abumrad NA, El-Maghrabi MR, Amri EZ, Lopez E, Grimaldi PA.  Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol. Chem. 268 (24):17665-68, 1993.

  • Ibrahimi A, Sfeir Z, Magharaie H, Amri EZ, Grimaldi P, Abumrad NA. Expression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transport. Proc. Natl. Acad. Sci. 93: 2646-51, 1996. PMCID: PMC39684

  • Abumrad N, Harmon C, Ibrahimi A. Membrane transport of long-chain fatty acids: evidence for a facilitated process. J Lipid Res. 39: 2309-18, 1998.

Demonstration of the physiological importance of CD36-mediated FA uptake:

  • Ibrahimi A, Bonen A, Blinn WD, Hajri T, Li X, Zhong K, Cameron R, Abumrad NA. Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin. J Biol Chem. 274(38):26761-6, 1999.

  • Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, Scott J. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet. 21(1):76-83, 1999.

  • Hajri T, Han XX, Bonen A, Abumrad NA. Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest 109:1381-1389, 2002. 

  • Abumrad NA, Goldberg IJ. CD36 actions in the heart: Lipids, calcium, inflammation, repair and more? Biochim Biophys Acta 1860: 1442-9, 2016.  PMCID: PMC4983248

CD36 regulates fat absorption and gut homeostasis: 

  • Drover VA, Ajmal M, Nassir F, Davidson NO, Nauli AM, Sahoo D, Tso P, Abumrad NA. CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest 115(5):1290-7, 2005. 

  • Nauli AM, Nassir F, Zheng S, Yang Q, Lo CM, VonLehmden SB, Lee D, Jandacek RJ, Abumrad NA, Tso P. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology 131: 1197-1207, 2006.

  • Abumrad NA, Davidson NO. Role of the gut in lipid homeostasis. Physiological reviews 92: 1061-85, 2012.  PMCID:  3589762

  • Cifarelli V, Ivanov S, Xie Y, Son NH, Saunders BT, Pietka TA, Shew TM, Yoshino J, Sundaresan S,  Davidson NO, Goldberg IJ, Gelman AE, Zinselmeyer BH, Randolph GJ, Abumrad NA. CD36 Deficiency Impairs the Small Intestinal Barrier and Induces Subclinical Inflammation in Mice. Cellular and Molecular Gastroenterology and Hepatology, 3(1):82-98, 2017.  PMCID: 5217470

 

CD36 contributes an important genetic component of metabolic regulation in humans:

  • Love-Gregory L, Sherva R, Sun L, Wasson J, Schappe T, Doria A, Rao DC, Hunt SC, Klein S,  Neuman RJ, Permutt MA, Abumrad NA. Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum. Mol. Genetics 17: 1695-04, 2008. PMCID: 265528.

  • Pepino MY, Love-Gregory L, Klein S, Abumrad NA. The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects. J. Lipid Res. 53: 561-566, 2012. PMCID: 3276480

  • Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA. A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition. J Clin Endocrinol Metab. 101:2751-8, 2016  PMCID: 4929841

  • Love-Gregory L, Kraja AT, Allum F, Aslibekyan S, Hedman ÅK, Duan Y, Borecki IB, Arnett DK, McCarthy MI, Deloukas P, Ordovas JM, Hopkins PN, Grundberg E, Abumrad NA. Higher chylomicron remnants and LDL particle numbers associate with common CD36 SNPs and DNA methylation sites that reduce CD36 expression. J Lipid Res. 57:2176-2184, 2016.  PMC In Process

FA-sensitive CD36 signal transduction in metabolic regulation:

  • Kuda O, Pietka TA, Demianova Z, Kudova E, Cvacka J, Kopecky J, Abumrad NA.  Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages. J Biol Chem. 288:15547-55, 2013.  PMCID:  3668716.

  • Sundaresan S, Shahid R, Riehl TE, Chandra R, Nassir F, Stenson WF, Liddle RA, Abumrad NA. CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB J. 27(3):1191-202, 2013. PMCID: 3574291

  • Pepino MY, Kuda O, Samovski D, Abumrad NA. Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism. Ann. Rev. Nutr. 34: 281-303, 2014.  PMCID:  4329921.

  • Samovski D, Sun J, Pietka T, Gross RW, Eckel RH, Su X, Stahl PD, Abumrad NA. Regulation of AMPK activation by CD36 links fatty acid uptake to β-oxidation. Diabetes. 64:353-9, 2015.  PMCID:  4303974.

 

Complete List of Published Work:  https://www.ncbi.nlm.nih.gov/pubmed?term=Abumrad%20NA%5BAuthor%5D